LYMPHOMA

Lymphoma is a cancer that affects the lymphatic system. The lymphatic system forms part of the immune system that  helps protect us from infections and diseases. Lymphoma is not infectious and cannot be passed on to other people.

Types of Lymphoma

There are many types of lymphoma but there are two main sub-types:

Hodgkin lymphoma

Formerly known as Hodgkin’s disease, it is one of the most common types of lymphoma.  It usually starts in the lymph nodes in the neck but can affect other body parts. It is more common in people between 20-40 years and people aged 55 and over. This type can also be further classified into classical and Nodular lymphocyte predominant Hodgkin lymphoma

Non -Hodgkin lymphoma

This is more common than the other type and usually starts from the lymphocytes-a white blood cell. Some grow slowly and may not need treatment for a long time while others may grow rapidly. There are different subtypes of non-Hodgkin’s lymphoma, of which follicular and Diffuse large B-cell lymphoma are types.

Symptoms of Lymphoma:

The symptoms of Lymphoma will depend on the type of Lymphoma and its location in the body. Some of the symptoms might include :

  • regular cough, difficulty swallowing or breathlessness, if the lymphoma is in the chest area
  • Painless swollen glands (lymph nodes), often in the neck, armpit, or groin
  • Shortness of breath
  • Fever
  • indigestion, tummy pain or weight loss, if the lymphoma is in the stomach or bowel.
  • Night sweats
  • Fatigue
  • Weight loss
  • Itching

Causes of Lymphoma

There is no exact cause of lymphoma but it starts when the lymphocyte mutates rapidly. The following are factors that can increase the risk of lymphoma 

Gender

This type of cancer seems to be more common in men than women.

 Age 

Hodgkin lymphoma is more common in people who are 20 to 34 years old or over 70 years old While Non-Hodgkin lymphoma is common in those in their 50s or older.

Exposure to harmful substances

If you were exposed to benzene or chemicals that kill bugs and weeds

Exposure to radiation 

if you were previously treated for cancer with radiation

A weakened immune system

The risk of developing lymphoma may be higher if the body’s immune system is weak. An immune system may be weak as a result of  HIV/AIDS, an organ transplant, or as a result of taking immunosuppressants.

Auto-immune disease 

When the immune system attacks healthy body tissue by mistake, this can cause an Auto-immune disease. e.g. rheumatoid arthritis, Sjögren’s syndrome, lupus, or celiac disease

Certain infections

Having infections like the Epstein-Barr virus and Helicobacter pylori infection can significantly increase the risk of getting lymphoma.

Diagnosis

Your doctor may carry out the following tests if you have symptoms of lymphoma:

Lymph node testing:

Your doctor may take out some tissue from,  part of  or all of a swollen lymph node to test for cancer in the laboratory.

Bone marrow sample:

A sample of bone marrow is removed from your hipbone using a needle and analysed to check for lymphoma.

Blood tests:

Your doctor may carry out blood tests to check your cells.

Imaging tests:

Your doctor may recommend imaging tests like CT,MRI and PET scans to get clearer pictures of the extent of the cancer in your body.

Staging

Stage 1:

This means cancer is just in only one group of lymph nodes in the neck, or anywhere else in the body

Stage 2:

This means that the cancer is in two or more groups of lymph nodes. They can be anywhere in the body but on the same side of the diaphragm.

Stage 3:

The cancer has spread to more lymph nodes and extended to the other side of the diaphragm.

Stage 4:

This means the lymphoma has spread to one or more organs outside the lymphatic system. For e.g. liver, lungs or bones.

Also you may have the letters ‘A’ or ‘B’ after your stage. “A” is put after your stage if you have no additional symptoms other than swollen lymph nodes. “B” is put after your stage if you have additional symptoms of weight loss, fever or night sweats.

Treatment for Lymphoma

Watchful waiting

Some types of lymphoma do not grow quick and your doctor may  advise to keep monitoring your condition until you start showing symptoms.

Chemotherapy

This involves using cytotoxic drugs to kill the cancer cells. They can be taken as a pill or injected through a vein.

Radiotherapy

This uses high-energy X-rays or protons to destroy the  cancer cells.

Immunotherapy

This involves triggering the immune system to kill and destroy the cancer cells.

Bone marrow transplant

This procedure involves using healthy stem cells from your body or donor to rebuild your bone marrow. Normally chemoradiation is often used to suppress your bone marrow.

REFERENCES

https://www.mayoclinic.org/diseases-conditions/lymphoma/diagnosis-treatment/drc-20352642

https://lymphoma-action.org.uk/about-lymphoma-tests-diagnosis-and-staging/stages-lymphoma

https://www.macmillan.org.uk/cancer-information-and-support/lymphoma#diagnosis_of_lymphoma

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